GLOMERULAR ANGIOTENSIN-II RECEPTORS IN GENTAMICIN-INDUCED RENAL-FAILURE IN THE RAT

We evaluated the properties of glomerular angiotensin II receptors in renal glomeruli isolated from control rats and from rats with gentamic in-induced renal failure. There were no differences in the affinity of angiotensin Il for its receptor between glomeruli from control and th ose front rats treated with gentamicin. Angiotensin II receptor densit y was lower in glomeruli from rats with renal failure than in those fr om control rats (985 +/- 71 in gentamicin treated rats vs. 1602 +/- 21 3 fmol/mg prot in controls). No significant differences were observed in renin activity in the supernatant from glomeruli isolated from cont rol rats (3.74 +/- 0.29 ng angiotensin I/mL h) and those isolated from rats with gentamicin-induced renal failure (2.99 +/- 0.29 ng angioten sin I/mL h, p > 0.1). These findings do not support the contention of a role of angiotensin II in the development and maintenance of gentami cin-induced ARF`.