STIMULATORY EFFECTS OF AMPHETAMINE ON THE DEVELOPMENT OF WALKER-256 CARCINOMA LUNG METASTASES IN RATS

Authors
FREIREGARABAL M NUNEZIGLESIAS MJ LOSADA C PEREIRORAPOSO MD CASTROBOLANO C HERAS J RIVEIRO P MAYAN JM REYMENDEZ M
Citation
M. Freiregarabal et al., STIMULATORY EFFECTS OF AMPHETAMINE ON THE DEVELOPMENT OF WALKER-256 CARCINOMA LUNG METASTASES IN RATS, Oncology Reports, 3(1), 1996, pp. 201-204
Citations number
23
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
3
Issue
1
Year of publication
1996
Pages
201 - 204
Database
ISI
SICI code
1021-335X(1996)3:1<201:SEOAOT>2.0.ZU;2-O
Abstract
Experiments were performed in order to evaluate the effects of ampheta mine (0.4 mg/kg/day) on the development of lung metastases in rats inj ected i.v. with 10(4) Walker 256 (W-256) carcinosarcoma cells, The num ber of metastatic nodules on the surface of the lungs, as well as the percentage-area of metastases in the frontal section through pulmonary hilus were increased in rats injected with amphetamine in comparison with those injected with placebo. Survival periods were also assessed and amphetamine was found to increase the lethality of rats.