Gr. Pettit et al., ISOLATION AND CRYSTAL-STRUCTURE OF STYLOPEPTIDE-1, A NEW MARINE PORIFERA CYCLOHEPTAPEPTIDE, Journal of organic chemistry, 60(25), 1995, pp. 8257-8261
Stylopeptide 1 (1) was isolated respectively from the South and Wester
n Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structur
al determination was accomplished by utilizing high-field (500 MHz) 2D
-NMR experiments and confirmed by an X-ray crystal structure determina
tion to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The
absolute configuration of the new cycloheptapeptide was established b
y employing results of chiral gas chromatographic analyses.