MEDICAL-TREATMENT OF SQUAMOUS HYPERPLASIA AND LICHEN-SCLEROSUS OF THEVULVA

Objective: To evaluate the efficacy of medical treatment in patients w ith lichen sclerosus (LS), squamous hyperplasia (SH) and lichen sclero sus with associated squamous hyperplasia. Methods: Forty-eight patient s with non-neoplastic epithelial disorders of the vulva, SH in 23 (47. 9%), LS in 20 (41.6%) and LS with associated SH in five (10.5%) were d iagnosed and treated in our clinic. Patients with LS were treated with 2% testosterone ointment. Topical fluorinated corticosteroids was the treatment of choice in patients with SH. Patients with LS with associ ated SH were treated with topical fluorinated corticosteroid applicati on followed by testosterone propionate ointment. Results: The clinical response rate of SH to first-line therapy was 95.6% with a correlatio n of 90.5% with histological reversal; this rate was 80% with a histol ogical correlation of 81.3% in LS. The remission rates of SH and LS pa tients following a full course of therapy were 100% and 90%, respectiv ely. In LS with associated SH patients, 90% responded to standard ther apy with a remission rate of 100% after completion of a full course of therapy. Conclusion: Medical therapy of lichen sclerosus and squamous hyperplasia was very effective with a good clinical and histologic co rrelation.