Ys. Li et al., CYTOGENETIC EVIDENCE THAT A TUMOR-SUPPRESSOR GENE IN THE LONG ARM OF CHROMOSOME-1 CONTRIBUTES TO GLIOMA GROWTH, Cancer genetics and cytogenetics, 84(1), 1995, pp. 46-50
In a patient with a rare subtype of glioma, pleomorphic xanthoastrocyt
oma, cytogenetic studies revealed that both homologues of chromosome 1
were involved in translocations at the same band 1q42 but with differ
ent partner chromosomes. In addition, 5 glioblastomas out of 25 glioma
s karyotyped in our laboratory had lost at least one copy of band 1q42
through deletions, unbalanced rearrangements, or chromosome losses. T
wenty-one gliomas that had lost at least one copy of chromosome band 1
q42 were identified in the literature; all were astrocytic tumors and
the majority were glioblastomas. It indicates a covert tumor suppresso
r gene in the region that is involved in astrocytic gliomas.