SOLID-PHASE SYNTHESIS OF ALKENES USING THE HORNER-WADSWORTH-EMMONS REACTION AND MONITORING BY GEL PHASE P-31 NMR

Authors
JOHNSON CR ZHANG BR
Citation
Cr. Johnson et Br. Zhang, SOLID-PHASE SYNTHESIS OF ALKENES USING THE HORNER-WADSWORTH-EMMONS REACTION AND MONITORING BY GEL PHASE P-31 NMR, Tetrahedron letters, 36(51), 1995, pp. 9253-9256
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
51
Year of publication
1995
Pages
9253 - 9256
Database
ISI
SICI code
0040-4039(1995)36:51<9253:SSOAUT>2.0.ZU;2-V
Abstract
Phosphonoacetamide eaters bound to solid supported peptides or peptide synthesis supports are active as Horner-Wadsworth-Emmons (HWE) reagen ts with a variety of aldehydes. HWE reagents can be attached to the so lid support via the amide or phosphono eater. Mild basic conditions, t riethylamine and Li salts, with excess aldehyde give high conversions to alkenes.