KAINIC ACID AS CONFORMATIONALLY CONSTRAINED GLUTAMIC-ACID ANALOG IN PEPTIDE-SYNTHESIS

Authors
ARTUSO F SINDONA G ATHANASSOPOULOS C STAVROPOULOS G PAPAIOANNOU D
Citation
F. Artuso et al., KAINIC ACID AS CONFORMATIONALLY CONSTRAINED GLUTAMIC-ACID ANALOG IN PEPTIDE-SYNTHESIS, Tetrahedron letters, 36(51), 1995, pp. 9309-9312
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
51
Year of publication
1995
Pages
9309 - 9312
Database
ISI
SICI code
0040-4039(1995)36:51<9309:KAACCG>2.0.ZU;2-I
Abstract
A synthetic protocol is described which allows the incorporation of th e gamma-amide (Kan) and the gamma-benzyl ester [Kai(Bzl)] and ether [K ol(Bzl)] of kainic acid (Kai) into peptide chains as exemplified with the synthesis of the substance P (SP) analogs [Kan(5)]-SP5-11, [Glp(5) , Kan(6)]-SP5-11, [Kan(6)]-SP6-11, [Glp(5), Kai(Bzl)(11)]-SP5-11 and [ Glp(5), Kol(Bzl)(11)]-SP5-11.