TOTAL SYNTHESES OF POLYAMINE AMIDES PHTX-4.3.3 AND PHTX-3.4.3 - REDUCTIVE ALKYLATION IS A RAPID, PRACTICAL ROUTE TO PHILANTHOTOXINS

Authors
MOYA E BLAGBROUGH IS
Citation
E. Moya et Is. Blagbrough, TOTAL SYNTHESES OF POLYAMINE AMIDES PHTX-4.3.3 AND PHTX-3.4.3 - REDUCTIVE ALKYLATION IS A RAPID, PRACTICAL ROUTE TO PHILANTHOTOXINS, Tetrahedron letters, 36(51), 1995, pp. 9401-9404
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
51
Year of publication
1995
Pages
9401 - 9404
Database
ISI
SICI code
0040-4039(1995)36:51<9401:TSOPAP>2.0.ZU;2-W
Abstract
Reductive alkylation allows a rapid and practical entry to the polyami ne amide wasp toxin philanthotoxin-4.3.3. Philanthotoxin-3.4.3 has bee n prepared, in two steps, by the monoacylation of spermine. These poly amine amides are selective molecular pharmacological tools for cation channels gated by glutamic acid and acetylcholine, and may have potent ial as neuroprotective agents.