DITHIOLANE-ISOCYANATE IMMINIUM METHYLIDES - A RAPID STEREOSELECTIVE ENTRY INTO GAMMA-LACTAMS

Authors
FISHWICK CWG FOSTER RJ CARR RE
Citation
Cwg. Fishwick et al., DITHIOLANE-ISOCYANATE IMMINIUM METHYLIDES - A RAPID STEREOSELECTIVE ENTRY INTO GAMMA-LACTAMS, Tetrahedron letters, 36(51), 1995, pp. 9409-9412
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
51
Year of publication
1995
Pages
9409 - 9412
Database
ISI
SICI code
0040-4039(1995)36:51<9409:DIM-AR>2.0.ZU;2-X
Abstract
Methods have been developed for the generation and trapping of dithiol ane-isocyanate imminium methylides which are a new type of azomethine methylide-derived 1,3-dipole. These species add efficiently and stereo selectively to electron deficient olefins yielding novel dithiolane-pr otected gamma-lactans which can be efficiently deprotected to yield to corresponding lactam systems.