LOBAR VARIATION OF CARBON-TETRACHLORIDE HEPATOTOXICITY IN THE RAT

The lobar variation in carbon tetrachloride-induced liver damage in th e rat has been assessed by use of a systematic random sampling protoco l and quantitative morphometry. A random inter-animal lobar variation in severity of damage was apparent, in contrast with the results obtai ned previously in which sampling bias, small animal numbers, and lack of fully quantitative measurement were apparent. The route of administ ration (oral vs. i.p.) did not influence these findings.