REGULATION OF HEPATIC INTRACELLULAR PH AT HYPOTHERMIA - A COMPARISON OF HIBERNATING AND NON-HIBERNATING SPECIES USING P-31 NMR-SPECTROSCOPY

Authors
FULLER BJ BUSZA AL LOCKETT CJ SIMPKIN S WANG LH GREEN CJ
Citation
Bj. Fuller et al., REGULATION OF HEPATIC INTRACELLULAR PH AT HYPOTHERMIA - A COMPARISON OF HIBERNATING AND NON-HIBERNATING SPECIES USING P-31 NMR-SPECTROSCOPY, Cryo-letters, 16(6), 1995, pp. 323-328
Citations number
15
Categorie Soggetti
Biology Miscellaneous",Physiology
Journal title
Cryo-letters → ACNP
ISSN journal
01432044
Volume
16
Issue
6
Year of publication
1995
Pages
323 - 328
Database
ISI
SICI code
0143-2044(1995)16:6<323:ROHIPA>2.0.ZU;2-J
Abstract
Liver metabolism at hypothermia was studied in vitro in livers from no rmal rat and hibernating squirrels using P-31 NMR spectroscopy. During continuous perfusion at 6-8 degrees C with oxygenated buffer, livers from both species maintained levels of high-energy phosphorylated aden ylates, while intrahepatic pH was shifted to values predicted from the 'alpha-stat' hypothesis. No specific differences in metabolism were d etected between the homeotherm and hibernating species.