ADENOSINE A(2A) RECEPTOR STIMULATION ENHANCES STRIATAL EXTRACELLULAR GLUTAMATE LEVELS IN RATS

Authors
POPOLI P BETTO P REGGIO R RICCIARELLO G
Citation
P. Popoli et al., ADENOSINE A(2A) RECEPTOR STIMULATION ENHANCES STRIATAL EXTRACELLULAR GLUTAMATE LEVELS IN RATS, European journal of pharmacology, 287(2), 1995, pp. 215-217
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
287
Issue
2
Year of publication
1995
Pages
215 - 217
Database
ISI
SICI code
0014-2999(1995)287:2<215:AARSES>2.0.ZU;2-R
Abstract
The influence of CGS 21680, an adenosine A(2A) receptor agonist, on st riatal glutamate extracellular levels was tested in a microdialysis st udy in rats. CGS 21680 (10 mu M), infused intrastriatally through the microdialysis probe, greatly enhanced glutamate extracellular levels. These results show that striatal adenosine A(2A) receptors are involve d in the regulation of striatal glutamate extracellular levels. They a lso suggest that adenosine A(2A) receptor antagonists may possess neur oprotective effects in models of striatal excitotoxicity.