EFFECTS OF OMEPRAZOLE AND LANSOPRAZOLE ON FASTING AND POSTPRANDIAL SERUM GASTRIN AND SERUM PEPSINOGEN-A AND PEPSINOGEN-C

Background/Aims: The aim of this study was to examine effects of two H +/K+-ATPase antagonists (omeprazole and lansoplazole) on fasting and p ostprandial serum gastrin and serum pepsinogens A and C. Materials and Methods: In 8 healthy volunteers, either 20 mg of omeprazole or 30 mg of lansoprazole once daily for 7 days were administered in a double b lind and randomized design. After a two-week period to ''wash out'' th e drug, each treatment was then crossed over. Fasting and postprandial serum gastrin and serum pepsinogens A and C levels were measured at b aseline and at the end of the treatment. Results: Omeprazole increased fasting levels of serum gastrin and serum pepsinogen A and C. A simil ar finding was observed after lansoprazole administration. The test me al increased serum gastrin level but did not serum pepsinogens A and C either before or after omeprazole and lansoprazole administration. In addition, the integrated meal stimulated incremental serum gastrin we re not modified after omeprazole and lansoprazole administration. Conc lusions: This data suggests that both omeprazole and lansoplazole incr ease fasting serum gastrin and serum pepsinogen A and C levels, but ha ve no effects on postprandial serum gastrin and pepsinogens levels.