Background/Aims: Massive ascites and pleural effusions are uncommon bu
t well-documented complications of chronic pancreatitis. The present s
tudy reviews the results of surgical management of pancreatic ascites
and pleural effusions of pancreatic origin. Patients and Materials: Fr
om forty-nine patients with chronic pancreatitis presenting with ascit
es and/or pleural effusion of pancreatic origin, 31 were surgically tr
eated. Results: Nineteen had ascites only, ten pleural effusions and t
wo presented with both conditions. Diagnosis of the internal pancreati
c fistula was based on the findings of high amylase levels and elevate
d albumin content of the peritoneal and pleural exudates. Failure of m
edical therapy was the indication. of surgical treatment in all patien
ts. Thirteen were submitted to internal pancreatic drainage, 17 to ext
ernal drainage and one to distal pancreatic resection. Eight of 17 ext
ernally drained patients were reoperated for intraperitoneal abscesses
(2), infected pseudocyst (1), pain, recurrence (3) and pancreatic fis
tula (2);whereas reoperation occurred in only one of the 13 patients s
ubmitted to internal drainage (p < 0.05). Conclusions: Internal pancre
atic drainage was the ideal surgical treatment for patients with pancr
eatic ascites and/or pleural effusion that did not. respond to medical
treatment. When this was not feasible external drainage teas successf
ully used as an alternative to pancreatic resection.