INTERACTION BETWEEN NAPROXEN AND CHEMICALLY-MODIFIED BETA-CYCLODEXTRINS IN THE LIQUID AND SOLID-STATE

The complexation between naproxen and some chemically modified beta-cy clodextrins (hydroxyethyl beta-cyclodextrin with average substitution degree per anhydroglucose unit 0.6, 1.0 and 1.6; hydroxyproyl beta-cyc lodextrin with average substitution degree per anhydroglucose unit 0.6 and 0.9) was studied using phase-solubility analysis and molecular mo delling. The amorphous carriers exhibit similar solubilizing effects a nd complexing abilities, which are reflected by a comparable increase in drug dissolution rate to about the same extent from equimolar blend s with each chemically modified beta-cyclodextrin. X-ray diffractometr y and differential scanning calorimetry data indicate a role of the de gree of substitution of the carrier in the decrease in crystallinity o f naproxen in equimolar blends with chemically modified beta-cyclodext rins.