AGE-RELATED-CHANGES OF OXYGEN-FREE RADICAL PRODUCTION IN THE RAT-BRAIN SLICE AFTER HYPOXIA - ONLINE MEASUREMENT USING ENHANCED CHEMILUMINESCENCE

Authors
SCHREIBER SJ MEGOW D RAUPACH A VICTOROV IV DIRNAGL U
Citation
Sj. Schreiber et al., AGE-RELATED-CHANGES OF OXYGEN-FREE RADICAL PRODUCTION IN THE RAT-BRAIN SLICE AFTER HYPOXIA - ONLINE MEASUREMENT USING ENHANCED CHEMILUMINESCENCE, Brain research, 703(1-2), 1995, pp. 227-230
Citations number
28
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
703
Issue
1-2
Year of publication
1995
Pages
227 - 230
Database
ISI
SICI code
0006-8993(1995)703:1-2<227:AOORPI>2.0.ZU;2-6
Abstract
Superoxide radical production in brain slices of 12-, 24- and 60-day-o ld rats was measured online during and after 15 min of hypoxia with lu cigenin enhanced chemiluminescence. We found a typical radical burst a fter reoxygenation which developed with aging and is almost nonexisten t in the youngest and most prominent in the oldest group. This cannot be explained by a decreasing tissue superoxide dismutase (SOD) concent ration in the brain with aging, since the concentration of the enzyme, determined in the same age groups, increased with age.