SEX REVERSAL IN C57BL 6J-Y-POS MICE CORRECTED BY A SRY TRANSGENE/

Citation
Em. Eicher et al., SEX REVERSAL IN C57BL 6J-Y-POS MICE CORRECTED BY A SRY TRANSGENE/, Philosophical transactions-Royal Society of London. Biological sciences, 350(1333), 1995, pp. 263-268
Citations number
21
Categorie Soggetti
Biology
ISSN journal
09628436
Volume
350
Issue
1333
Year of publication
1995
Pages
263 - 268
Database
ISI
SICI code
0962-8436(1995)350:1333<263:SRIC6M>2.0.ZU;2-9
Abstract
C57BL/6J mice carrying a Mus domesticus poschiavinus Y chromosome (Y-P OS) develop as females with ovarian tissue or as hermaphrodites with o varian and testicular tissue. We tested the hypothesis that the Y-link ed component of this inherited sex reversal is caused by the M. d. pos chiavinus Y-linked testis determining gene (symbolized Tdy or Sry) by examining gonadal development in C57BL/6J XY(POS) mice carrying a-M. m usculus allele of Sry as a transgene. We found that in the presence of the transgene, XY(POS) mice developed exclusively testicular tissue. This result indicates that the Sry allele carried on the Y-POS chromos ome is responsible for development of ovarian tissue in the C57BL/6J i nbred strain background. We discuss this finding in light of DNA polym orphisms present in Sry alleles carried by various M. domesticus and M . musculus Y chromosomes. In addition, we present a hypothesis concern ing the timing of expression of the testicular and ovarian determining genes in the developing fetal gonad based on the organization of ovar ian and testicular tissue in ovotestes.