GUMMIFEROL, A CYTOTOXIC POLYACETYLENE FROM THE LEAVES OF ADENIA-GUMMIFERA

Authors
FULLAS F BROWN DM WANI MC WALL ME CHAGWEDERA TE FARNSWORTH NR PEZZUTO JM KINGHORN AD
Citation
F. Fullas et al., GUMMIFEROL, A CYTOTOXIC POLYACETYLENE FROM THE LEAVES OF ADENIA-GUMMIFERA, Journal of natural products, 58(10), 1995, pp. 1625-1628
Citations number
10
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
10
Year of publication
1995
Pages
1625 - 1628
Database
ISI
SICI code
0163-3864(1995)58:10<1625:GACPFT>2.0.ZU;2-8
Abstract
A new polyacetylenic diepoxide compound, gummiferol [1] was isolated f rom the leaves of Adenia gummifera by KB cytotoxicity-guided fractiona tion. Compound 1 exhibited significant activity against the KB human c ell line and a broad cytotoxic spectrum against other human cancer cel l lines. The structure of 1 was established primarily on the basis of its spectral data.