CHARACTERIZATION OF CHROMOSOME-11 WITH A COMPLEX INVERSION AND DELETION IN AN AML [M2] USING FLUORESCENCE IN-SITU HYBRIDIZATION

We report on a new case of AML [M2] where chromosome 11 was rearranged in a highly complex manner involving band 11q23. Routine G banding fa iled to identify the nature of this aberration which later was accompl ished using whole chromosome 11-specific painting probe by the FISH te chnique. Chromosome 11 band q23 is frequently involved in reciprocal t ranslocations with various chromosomes, but to have sole morbidity of such a complex nature is an atypical finding in AML [M2]. The band q23 of chromosome 11 involves the mixed lineage leukemia gene and rearran gement of this chromosomal region has been found in a variety of neopl asias. Henceforth, its precise identification has become imperative fo r classification of hematological malignancies and in turn to devise t herapeutic strategies.