COCAINE-INDUCED CHANGES IN TIME-COURSE OF REGIONAL CEREBRAL BLOOD-VOLUME AND TRANSIT-TIME AS DETERMINED BY DYNAMIC MR-IMAGING

Authors
LI KL SUOJANEN JN
Citation
Kl. Li et Jn. Suojanen, COCAINE-INDUCED CHANGES IN TIME-COURSE OF REGIONAL CEREBRAL BLOOD-VOLUME AND TRANSIT-TIME AS DETERMINED BY DYNAMIC MR-IMAGING, Journal of magnetic resonance imaging, 5(6), 1995, pp. 715-718
Citations number
NO
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Journal of magnetic resonance imaging → ACNP
ISSN journal
10531807
Volume
5
Issue
6
Year of publication
1995
Pages
715 - 718
Database
ISI
SICI code
1053-1807(1995)5:6<715:CCITOR>2.0.ZU;2-5
Abstract
We examined cocaine-mediated changes in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rat s using functional MR imaging techniques. Changes in MTT and rCBV in a nimals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine-mediated changes in extracellular dopam ine concentrations.