EFFECT OF RADIATION ON BLOOD-VOLUME IN LOW-GRADE ASTROCYTOMAS AND NORMAL BRAIN-TISSUE - QUANTIFICATION WITH DYNAMIC SUSCEPTIBILITY CONTRASTMR-IMAGING

OBJECTIVE. The purpose of this study was to determine whether it is po ssible to measure radiation-induced changes in blood volume in low-gra de astrocytomas and in normal brain tissue. SUBJECTS AND METHODS. The passage of a bolus of gadopentetate dimeglumine was monitored on a ser ies of 55 T2-weighted simultaneous dual fast low-angle shot MR images with a standard 1.5-7 MR imaging system, Absolute blood volumes were calculated as the area under the tissue concentration-time curve in re gions of interest and normalized to the arterial input function. We pe rformed 41 examinations on 19 patients with grade II astrocytomas. For comparison, 13 patients were studied after whole brain irradiation. R ESULTS. A reduction in blood volume (mean +/- SD in milliliters per 10 0 g) within the tumors from 12.2 +/- 8.7 to 6.5 +/- 5.3 after fraction ated conformation radiotherapy was detected, although there was no con sistent pattern in different patients. An insignificant reduction was noted in normal gray (9.2 +/- 2.8 to 7.4 +/- 3.2) and white (4.4 +/- 1 .9 to 4.1 +/- 2.3) matter outside the target volume. Conversely, we ob served a significantly lower blood volume in gray (6.3 +/- 1.2) and wh ite (3.1 +/- 1.0) matter after whole brain radiotherapy. CONCLUSION. O ur results show that a reduction of blood volume in astrocytomas and n ormal brain tissue after radiotherapy can be quantified by use of dyna mic susceptibility contrast MR imaging. Thus, functional monitoring of tumor response and of normal tissue effects becomes possible.