PUERPERAL CEREBRAL VENOUS THROMBOSIS ASSOCIATED WITH DECREASED FREE PROTEIN-S - A CASE-REPORT

BACKGROUND: Cerebral venous thrombosis is a rare event with multiple r isk factors. This condition can be associated with a hypercoagulable s tate, such as that seen with dysfunctional or decreased plasma protein C and protein S. Both plasma proteins ave naturally occurring, vitami n K-dependent anticoagulants that are important for regulation of the clotting cascade. CASE: A postpartum patient presented with complaints of a severe headache and hypertension and later developed status epil epticus. She was found to have superior sagittal sinus and right inter nal jugular vein thrombosis and protein S deficiency. CONCLUSION: The combination of protein S deficiency and the further reduction due to p regnancy may enhance the risk of major thrombotic episodes in the peri partum period.