Hl. Galan et al., PUERPERAL CEREBRAL VENOUS THROMBOSIS ASSOCIATED WITH DECREASED FREE PROTEIN-S - A CASE-REPORT, Journal of reproductive medicine, 40(12), 1995, pp. 859-862
BACKGROUND: Cerebral venous thrombosis is a rare event with multiple r
isk factors. This condition can be associated with a hypercoagulable s
tate, such as that seen with dysfunctional or decreased plasma protein
C and protein S. Both plasma proteins ave naturally occurring, vitami
n K-dependent anticoagulants that are important for regulation of the
clotting cascade. CASE: A postpartum patient presented with complaints
of a severe headache and hypertension and later developed status epil
epticus. She was found to have superior sagittal sinus and right inter
nal jugular vein thrombosis and protein S deficiency. CONCLUSION: The
combination of protein S deficiency and the further reduction due to p
regnancy may enhance the risk of major thrombotic episodes in the peri
partum period.