We examined the effects of breath holding against a closed glottis (Va
lsalva's manoeuvre) on intraocular pressure (IOP) in four groups of vo
lunteer subjects: 37 healthy young control subjects, 10 patients with
chronic open-angle glaucoma, 11 age-matched control subjects and 8 gla
ucoma suspects. IOP was recorded by one person using a Digilab 30R/T P
neuma-Tonometer. Chart recordings of the IOP were measured independent
ly by a second investigator. Recordings were taken before, during and
5 minutes after the seated subject exhaled into an aneroid manometer t
o a pressure of 25 to 35 cm H2O. There was marked variability in the i
ndividual responses to Valsalva's manoeuvre in all four groups, with s
ubstantial increases (to +9.5 mm Hg) and decreases (to -4.0 mm Hg) in
IOP seen. The mean change in IOP during Valsalva's manoeuvre was a sma
ll, statistically insignificant decrease in all four groups. The mean
change in IOP following Valsalva's manoeuvre was a larger, but still c
linically small, decrease. The clinician should be aware of the indivi
dual variability in IOP changes with Valsalva's manoeuvre.