ADDUCTS OF ORGANOTIN(IV), TIN(IV) AND TIN(II) HALIDES WITH 1-METHYL-IMIDAZOLINE-2(3H)-THIONE (HMIMT) AND IMIDAZOLINE-2(1,3H)-THIONE (HIMT) - SYNTHESIS, SPECTROSCOPIC (IR, MOSSBAUER AND H-1, C-13, SN-119 NMR) STUDIES AND IN-VITRO ANTITUMOR-ACTIVITY

The reactions of 1-methyl-imidazoline-2(3H)-thione (Hmimt) and imidazo line-2(1,3H) -thione (Himt) with organotin(IV), tin(IV) and tin(lI) ha lides were studied. Ten novel adducts were prepared and characterised by elemental analysis, conductivity measurements, IR, far-IR, H-1 NMR, C-13 NMR,Sn-119 NMR and Mossbauer spectroscopy. The ligands behave as monodentate and exhibit sulfur coordination. The structure of the com plexes, in the solid state, is discussed in terms of the Mossbauer qua drupole splitting and the tin-ligand stretching vibrations in the IR a nd far-IR spectra. The behaviour of the adducts upon dissolution to D2 O and CDCl3 is also discussed. Octahedral dimeric and monomeric stereo chemistries are assigned for organotin(IV) and tin(IV) adducts in the solid state. The in vitro antitumour activity against six human cell l ines, MCF-7, EVSA (two breast cancers), WiDr (a colon cancer), IGROV ( an ovarian cancer), M19MEL (a melanoma) and A498 (a renal cancer) for the adducts [SnBuCl(3)(Hmimt)](2), [SnMeCl(3)(Himt)](2) and SnMe(2)Cl( 2)(Himt)(2) is reported.