BIODEGRADATION OF POROUS VERSUS NONPOROUS POLY(L-LACTIC ACID) FILMS

The influence of porosity on the degradation rate of poly(L-lactic aci d) (PLLA) films was investigated in vitro and in vivo. Non-porous, por ous and ''combi'' (porous with a non-porous layer) PLLA films were use d. Changes in Mw, Mn, polydispersity (Mw/Mn) ratio, melting temperatur e (T(m)), heat of fusion, tensile strength, E-modulus, mass and the re maining surface area of cross-sections of the PLLA films were measured . In general, during the degradation process, the porous film has the highest Mw, Mn, Mw/Mn ratio and T(m), while the nonporous film has the lowest. In contrast, the highest heat of fusion values were observed for the non-porous film, indicating the presence of relatively smaller molecules forming crystalline domains more easily. The tensile streng th and E-modulus of the non-porous film decrease faster than those of the porous and the combi film. None of the three types of films showed massive mass loss in vitro nor a significant decrease in remaining po lymer surface area in light microscopical sections in vitro and in viv o. Heavy surface erosion of the non-porous layer of the combi film was observed after 1 80 days, turning the combi film into a porous film. This is also indicated by the changes in tensile strength, Mw, Mw/Mn, T(m) and heat of fusion as a function of time. It is concluded that no n-porous PLLA degrades faster than porous PLLA. Thus, in our model, po rosity is an important determinant of the degradation rate of PLLA fil ms.