The importance of classifying chronic gastritis is the causal relation
ship of some cases to pernicious anemia, peptic ulcer, and gastric ade
nocarcinoma. The morphology and topographic distribution of chronic ga
stritis form the basis for the current recognition of five subtypes. T
hese are: Type A or diffuse atrophic corporal; Type B or diffuse antra
l; Type AB or multifocal atrophic; and Type C chemical, reactive, and
lymphocytic. The etiology includes autoimmunity, bacterial infection,
bile reflux, the effects of nonsteroidal anti-inflammatory drugs, and
diet. There are, however, discrepancies in the evidence that these sub
types are entirely distinct. A multifactorial etiology for individual
cases and groups of cases is argued as the cause of difficulty in assi
gning cases to a specific type. The challenge still posed by chronic g
astritis is stressed.