STEREOSELECTIVE REDUCTION OF THE DOUBLE-BOND IN DELTA(5)-3-OXO-4-AZASTEROIDS

Authors
MORZYCKI JW WILCZEWSKA AZ ZOCHOWSKA E LOTOWSKI Z
Citation
Jw. Morzycki et al., STEREOSELECTIVE REDUCTION OF THE DOUBLE-BOND IN DELTA(5)-3-OXO-4-AZASTEROIDS, Heterocycles, 41(12), 1995, pp. 2729-2736
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
12
Year of publication
1995
Pages
2729 - 2736
Database
ISI
SICI code
0385-5414(1995)41:12<2729:SROTDI>2.0.ZU;2-P
Abstract
The stereoselective borohydride/H+ reduction of the C-(5) - C-(6) doub le bond in Delta(5)-3-oxo-4-azasteroids has been studied. The intermed iate acylimine is preferentially attacked by borohydride from the a si de. The optimization with respect to the type of borohydride, solvent, catalyst and temperature has been carried out.