OLIGONUCLEOTIDES CONTAINING ACYCLIC NUCLEOSIDE ANALOGS WITH CARBAMATEINTERNUCLEOSIDE LINKAGES

Authors
HABUS I AGRAWAL S
Citation
I. Habus et S. Agrawal, OLIGONUCLEOTIDES CONTAINING ACYCLIC NUCLEOSIDE ANALOGS WITH CARBAMATEINTERNUCLEOSIDE LINKAGES, Nucleosides & nucleotides, 14(9-10), 1995, pp. 1853-1859
Citations number
42
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
9-10
Year of publication
1995
Pages
1853 - 1859
Database
ISI
SICI code
0732-8311(1995)14:9-10<1853:OCANAW>2.0.ZU;2-W
Abstract
Synthesis of 2'-deoxy-2',3'-secothymidine t and its dimer tt, where t he two 2'-deoxy-2',3'-secothymidine t units are connected via a carbam ate, =3'-NH-CO-O-5', internucleoside linkage has been achieved. These building blocks were protected in the 5'-position, converted into the ir phosphoramidites, or attached onto CPG, and then used for ''chimeri c oligonucleotide'' synthesis.