Fg. Rong et al., SYNTHESIS AND BIOCHEMICAL-ACTIVITY OF 5-TETHERED CARBORANE-CONTAININGPYRIMIDINE NUCLEOSIDES AS POTENTIAL AGENTS FOR DNA INCORPORATION, Nucleosides & nucleotides, 14(9-10), 1995, pp. 1873-1887
Synthesis and biochemical evaluation of a series of 5-tethered carbora
ne-containing pyrimidine nucleosides have been undertaken. The biochem
ical studies with human TK demonstrated that these compounds can be ph
osphorylated to the corresponding 5'-monophosphate and that the most s
ignificant conversion occurred when seven atoms were inserted between
the carborane cage and the pyrimidine base, and of these the best was
the one with saturated ester.