BUILDING-BLOCKS FOR SYNTHESIS OF OLIGOARABINONUCLEOTIDES - PREPARATION OF ARABINONUCLEOSIDE H-PHOSPHONATES FROM PROTECTED RIBONUCLEOSIDES

Authors
ROZNERS E BIZDENA E
Citation
E. Rozners et E. Bizdena, BUILDING-BLOCKS FOR SYNTHESIS OF OLIGOARABINONUCLEOTIDES - PREPARATION OF ARABINONUCLEOSIDE H-PHOSPHONATES FROM PROTECTED RIBONUCLEOSIDES, Nucleosides & nucleotides, 14(9-10), 1995, pp. 2009-2025
Citations number
27
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
9-10
Year of publication
1995
Pages
2009 - 2025
Database
ISI
SICI code
0732-8311(1995)14:9-10<2009:BFSOO->2.0.ZU;2-3
Abstract
A straightforward and inexpensive synthesis of arabinonucleoside H-pho sphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2'-keto derivatives. Reaction condition s have been optimised for compounds bearing labile N-protections. Furt her protecting group manipulation and phosphonylation gave the require d H-phosphonate monomers.