SILYL ETHERS OF CYCLOHEPTENE, NOVEL PROTON PUMP INHIBITORS OBTAINED DURING THE TOTAL SYNTHESIS OF THE SCOPADULCIC ACIDS

Authors
HAYASHI T SUGIMOTO T TAKEWAKI N TAKEGUCHI N TRAN VD OCONNOR SJ RUCKER PV OVERMAN LE
Citation
T. Hayashi et al., SILYL ETHERS OF CYCLOHEPTENE, NOVEL PROTON PUMP INHIBITORS OBTAINED DURING THE TOTAL SYNTHESIS OF THE SCOPADULCIC ACIDS, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 2943-2946
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
2943 - 2946
Database
ISI
SICI code
0960-894X(1995)5:24<2943:SEOCNP>2.0.ZU;2-N
Abstract
Synthetic compounds with the scopadulan ring system showed inhibitory effects on the gastric proton pump when they have ether linkages at po sitions C-6, C-13 and/or C-18, Tert-butyl-dimethylsilyl ether of 5-met hylenecycloheptene and related compounds revealed to be novel proton p ump inhibitors.