CONVERGENT SYNTHESES AND CYTOSTATIC PROPERTIES OF 2-CHLORO-2'-DEOXY-2'-FLUOROADENOSINE AND ITS N-7-ISOMER

Authors
ZAITSEVA GV SIVETS GG KAZIMIERCZUK Z VILPO JA MIKHAILOPULO IA
Citation
Gv. Zaitseva et al., CONVERGENT SYNTHESES AND CYTOSTATIC PROPERTIES OF 2-CHLORO-2'-DEOXY-2'-FLUOROADENOSINE AND ITS N-7-ISOMER, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 2999-3002
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
2999 - 3002
Database
ISI
SICI code
0960-894X(1995)5:24<2999:CSACPO>2.0.ZU;2-S
Abstract
Glycosylation of trimethylsilylated 2,6-dichloropurine 2 with acetate 1 in anhydrous MeCN was investigated. In the presence of SnCl4, the re action was regio- and stereoselective affording N-7-beta-glycoside 3 ( 86%). The use of TMS-Tfl instead of SnCl4 afforded a approximate to 9. 1 mixture of the N-9-beta- and -alpha-glycosides 5 and 6 (90%, combine d). The title nucleosides were tested for their cytotoxicity.