RELATIONSHIP BETWEEN CYTOTOXICITY AND DNA-BINDING AFFINITY OF AMIDINEDERIVATIVES OF TETRAHYDROQUINO[4,3-B][1]BENZAZEPINES AND TETRAHYDROBENZO[K]NAPHTHYRIDIN

Authors
EIFLERLIMA VL URIAC P HUET J JENKINS TC THURSTON DE
Citation
Vl. Eiflerlima et al., RELATIONSHIP BETWEEN CYTOTOXICITY AND DNA-BINDING AFFINITY OF AMIDINEDERIVATIVES OF TETRAHYDROQUINO[4,3-B][1]BENZAZEPINES AND TETRAHYDROBENZO[K]NAPHTHYRIDIN, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3003-3006
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3003 - 3006
Database
ISI
SICI code
0960-894X(1995)5:24<3003:RBCADA>2.0.ZU;2-D
Abstract
Two sets of amidine derivatives of the non-planar tetracyclic systems : tetrahydroquino[4.3-b][1] benzazepine (I) and tetrahydrobenzo[k]naph thyridine (II), bearing three types of side chains (hydroxyl, amine an d alkyl) have been synthesized. All the compounds were found to posses s weak but significant DNA-binding affinity which correlated with in v itro cytotoxicity across two cell lines.