CYCLOPROCTOLIN AND [ALPHA-METHYL-L-TYR]-PROCTOLIN ARE POTENT ANTAGONISTS OF PROCTOLIN-INDUCED INOSITOL PHOSPHATE PRODUCTION IN LOCUST FOREGUT HOMOGENATES

Authors
HINTON JM OSBORNE RH ODELL B HAMMOND SJ BLAGBROUGH IS
Citation
Jm. Hinton et al., CYCLOPROCTOLIN AND [ALPHA-METHYL-L-TYR]-PROCTOLIN ARE POTENT ANTAGONISTS OF PROCTOLIN-INDUCED INOSITOL PHOSPHATE PRODUCTION IN LOCUST FOREGUT HOMOGENATES, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3007-3010
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3007 - 3010
Database
ISI
SICI code
0960-894X(1995)5:24<3007:CA[APA>2.0.ZU;2-R
Abstract
Proctolin, an insect pentapeptide, causes dose-dependent production of inositol trisphosphate and inositol tetrakisphosphate from locust for egut homogenates which was antagonised by nM cycloproctolin and [alpha -Me-L-Tyr]-proctolin, but not by [N-Me-Tyr]-proctolin. We propose that cycloproctolin exists in a conformation which resembles a beta-bulge loop and contains a cis-Pro.