THROMBOXANE MODULATING AGENTS .1. DESIGN OF 1-[(ARYLSULFONYL)AMINO] ALKYLINDOLE DERIVATIVES AS DUAL THROMBOXANE SYNTHASE INHIBITOR THROMBOXANE RECEPTOR ANTAGONISTS

Authors
DICKINSON RP DACK KN STEELE J
Citation
Rp. Dickinson et al., THROMBOXANE MODULATING AGENTS .1. DESIGN OF 1-[(ARYLSULFONYL)AMINO] ALKYLINDOLE DERIVATIVES AS DUAL THROMBOXANE SYNTHASE INHIBITOR THROMBOXANE RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3017-3022
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3017 - 3022
Database
ISI
SICI code
0960-894X(1995)5:24<3017:TMA.DO>2.0.ZU;2-1
Abstract
The design of a series of dual thromboxane synthase inhibitor/thrombox ane receptor antagonists based on an indole thromboxane synthase inhib itor template is described. The indole-5-propanoic acid derivatives 17 , 22 and 23 were found to be potent dual agents in vitro.