SYNTHESIS OF THIOPHENOL DERIVATIVES AS INHIBITORS OF HUMAN COLLAGENASE

Authors
HUGHES I HARPER GP KARRAN EH MARKWELL RE MILESWILLIAMS AJ
Citation
I. Hughes et al., SYNTHESIS OF THIOPHENOL DERIVATIVES AS INHIBITORS OF HUMAN COLLAGENASE, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3039-3042
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3039 - 3042
Database
ISI
SICI code
0960-894X(1995)5:24<3039:SOTDAI>2.0.ZU;2-M
Abstract
A series of peptidomimetic thiophenol derivatives has been prepared an d evaluated in vitro as inhibitors of human fibroblast collagenase. Ma ny of these compounds have IC50 values in the sub-micromolar range.