OLIGONUCLEOTIDE DUPLEX STABILITY CONTROLLED BY THE 7-SUBSTITUENTS OF 7-DEAZAGUANINE BASES

Authors
SEELA F RAMZAEVA N CHEN YM
Citation
F. Seela et al., OLIGONUCLEOTIDE DUPLEX STABILITY CONTROLLED BY THE 7-SUBSTITUENTS OF 7-DEAZAGUANINE BASES, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3049-3052
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3049 - 3052
Database
ISI
SICI code
0960-894X(1995)5:24<3049:ODSCBT>2.0.ZU;2-Q
Abstract
Oligonucleotides containing 7-substituted 7-deazaguanine residues (7-m ethyl, 7-iodol have been synthesized. The self-complementary octamer d (I(7)c(7)G-C)(4) containing 7-iodo-7-deaza-2'-deoxyguanosine forms a s tabilized duplex compared to the parent oligomer d(G-C)(4) (Delta T-m = +10 degrees C). Also the complex between the oligodeoxynucleotide d( I(7)c(7)G(5)-G) and poly(C) is stabilized (Delta T-m = +10 degrees) ov er that of d(c(7)G(5)-G) with poly(C).