AMINO ACID-DERIVED PIPREIDIDES AS NOVEL CCKB LIGANDS WITH ANXIOLYTIC-LIKE PROPERTIES

Authors
HOLLADAY MW BENNETT MJ BAI H RALSTON JW KERWIN JF STASHKO M MILLER TR ONEILL AB NADZAN AM BRIONI J LIN CW
Citation
Mw. Holladay et al., AMINO ACID-DERIVED PIPREIDIDES AS NOVEL CCKB LIGANDS WITH ANXIOLYTIC-LIKE PROPERTIES, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3057-3062
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3057 - 3062
Database
ISI
SICI code
0960-894X(1995)5:24<3057:AAPANC>2.0.ZU;2-M
Abstract
The development of a novel series of carbamoylamino acid benzoylpiperi dides as CCKB ligands is described. Selected members of the series ant agonized CCK8-induced calcium mobilization and showed efficacy in the mouse elevated-plus maze, a measure of potential anxiolytic activity.