AROMATIC GUANYL HYDRAZONES - SYNTHESIS, STRUCTURAL STUDIES AND IN-VITRO ACTIVITY AGAINST TRYPANOSOMA-CRUZI

A series of 22 aromatic guanyl hydrazones, prepared by condensation of several aldehydes with aminoguanidine hydrochloride, were fully chara cterized by NMR techniques and tested in vitro against the trypomastig ote form of Trypanosoma cruzi, the causative agent of Chagas disease. Most of the compounds, especially those without hydrogen bonding group s and possessing ortho-substitution, were significantly more active th an crystal violet (ID50 536 mu M). The most active compound has an ID5 0 value of 17 mu M (25 times more potent than gentian violet).