ENANTIODIFFERENTIATION OF DIHYDROPYRIDINE PAF ANTAGONISTS

Authors
COOPER K FRAY MJ PARRY MJ RICHARDSON K STEELE J
Citation
K. Cooper et al., ENANTIODIFFERENTIATION OF DIHYDROPYRIDINE PAF ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3085-3090
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3085 - 3090
Database
ISI
SICI code
0960-894X(1995)5:24<3085:EODPA>2.0.ZU;2-K
Abstract
The PAF antagonist activity of a series of enantiomeric dihydropyridin es is described. In the first example, 1, the PAF antagonist activity and calcium channel blocking activity reside in opposite enantiomers. Subsequent examples also display enantioselectivity and the SAR of the series is described.