SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF 4-ARYL SUBSTITUTED BENZ[B]AZEPINES - ANTAGONISTS AT THE STRYCHNINE-INSENSITIVE GLYCINE SITE

Authors
JACKSON PF DAVENPORT TW GARCIA L MCKINNEY JA MELVILLE MG HARRIS GG CHAPDELAINE MJ DAMEWOOD JR PULLAN LM GOLDSTEIN JM
Citation
Pf. Jackson et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF 4-ARYL SUBSTITUTED BENZ[B]AZEPINES - ANTAGONISTS AT THE STRYCHNINE-INSENSITIVE GLYCINE SITE, Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 3097-3100
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
24
Year of publication
1995
Pages
3097 - 3100
Database
ISI
SICI code
0960-894X(1995)5:24<3097:SABOAS>2.0.ZU;2-3
Abstract
A series of 4-arylbenz[b]azepine analogs were prepared and shown to ac t as antagonists at the strychnine-insensitive glycine receptor. The h eteroaryl substituted benz[b]azepine derivative 11 also showed excelle nt in vivo activity.