We explore constraints on inflationary models employing data on large
scale structure mainly from Cosmic Background Explorer (COBE) temperat
ure anisotropies and Infrared Asronomy Satellite (IRAS) selected galax
y surveys, taking care not to apply linear perturbation theory to data
in the nonlinear regime. In models where the tensor contribution to t
he COBE signal is negligible, we find the spectral index of density fl
uctuations n must exceed 0.82. Furthermore, in inflation models which
generate tensor fluctuations, these must contribute less than 20% of t
he signal seen by COBE. The data favor cold plus hot dark matter model
s with n close to unity and OMEGA(HDM) approximately 0.20-0.35. We pre
sent realistic grand unified theories, including supersymmetric versio
ns, which produce inflation with these properties.