Positron emission tomography (PET) is an emerging clinical imaging tec
hnique that is facing the challenges of expansion in a period of immin
ent health care contraction and reform. Although PET began showing uti
lity in clinical medicine in the mid-1980s [1], its proliferation into
mainstream medical practice has not matched that of other new imaging
technologies such as MR imaging. Many factors have contributed to thi
s, including the changing health care economy, the high cost of PET, t
he length of time it takes to develop a PET facility, and its inherent
complexity. In part because of the proliferation of the use of other
technologies and the general explosion of costs, insurance carriers ar
e now holding diagnostic techniques, including PET, to stricter standa
rds of efficacy. New techniques must show improvement in long-term out
come of patients, a difficult task for diagnostic tools. In addition t
o these issues, PET is an expensive technology that requires highly tr
ained multidisciplinary personnel. Questions have also been raised abo
ut the most appropriate mechanism for regulation of PET isotope prepar
ation, leading to speculation about future regulatory requirements. Th
e current pioneers of PET must meet these challenges in order for it t
o become a routine imaging technique. Because of its clinical value, P
ET will probably survive despite the challenges. For many reasons, tho
ugh, not every hospital should necessarily develop PET services. Conve
rsely, many hospitals without this technology should consider acquirin
g PEI. The purpose of this article is to identify the financial, opera
tional, and clinical challenges facing PET centers today, describe pot
ential organizational configurations that may enable PET to survive in
an antitechnology environment, and delineate which institutions shoul
d consider this new technology.