NEOCLERODANE DITERPENOIDS FROM SCUTELLARIA-GALERICULATA

Two new neo-clerodane diterpenoids, scutegalin C and D, have been isol ated from the acetone extract of the aerial parts of Scutellaria galer iculata. The structures of the new compounds were established by chemi cal and spectroscopic means as (13S, 19R)-6 alpha-acetoxy-4 alpha,18-e poxy-7 beta-tigloyloxy-neo-cleroda-(19-O-tigloyl)-19,2 alpha, 16,15-di hemiacetal (scutegalin C) and (13S,19R)-6 alpha-acetoxy-4 alpha,18-epo xy-neo-cleroda-(19-O-tigloyl)-19,2 alpha, 16,15-dihemiacetal (scutegal in D). The absolute stereochemistry of scutegallin C was determined by chemical correlation with the already known neo-clerodane scutegalin B.