As. Dayal et al., INTERFERON-GAMMA-SECRETING CELLS IN MULTIPLE-SCLEROSIS PATIENTS TREATED WITH INTERFERON BETA-1B, Neurology, 45(12), 1995, pp. 2173-2177
Fifteen percent of multiple sclerosis patients about to be treated wit
h interferon beta-lb exhibited elevated numbers of circulating interfe
ron-gamma-secreting cells, defined as a value that exceeded the mean v
alue for healthy controls by more than two standard deviations, Sixty
percent of patients receiving the drug exhibited elevated interferon-g
amma-secreting cell numbers during their first 2 months of treatment.
Values normalized after 3 months. Prednisone treatment during the firs
t month on the drug prevented the interferon-gamma-secreting cell surg
e.