We carried out a double-blind and placebo-controlled study of the effi
cacy of bromocriptine in the treatment of nonfluent aphasia. Seven pat
ients received bromocriptine (up to 60 mg/d) and an identical placebo
in a randomized order. End points were the number of content words, co
ntent units, and pauses >3 seconds during the description of a figure;
verbal naming; and verbal fluency. There were no significant benefits
of bromocriptine over placebo in any of the variables examined.