Objective: To examine the relationship between self-esteem and the psy
chosocial response to cancer. Methods: The authors review methodologic
al issues associated with measuring self-esteem in patients with cance
r and Examine existing empirical studies in light of these issues. Res
ults: Self-esteem in cancer has been variously viewed as an outcome va
riable, a mediator of other psychosocial outcomes, and as a personal r
esource that facilitates coping. Unidimensional measures of global sel
f-esteem have been most often employed in research studies, despite in
creasing recognition that self-esteem is multidimensional. Evaluation
of global self-esteem has generally revealed no differences between ca
ncer patients and controls. Aspects of multidimensional self-esteem, p
articularly body self-esteem, appears to be disturbed in many patients
with cancer. Conclusions: The clinical and theoretical literature hav
e emphasized the importance of self-esteem to the psychosocial respons
e to cancer. Empirical study of self-esteem in cancer has been limited
by conceptual and methodological issues. Strategies for future resear
ch are discussed.