PROBING SOLID-PHASE REACTIONS BY MONITORING THE IR BANDS OF COMPOUNDSON A SINGLE FLATTENED RESIN BEAD

The resolution of the IR spectra recorded on a single resin bead is gr eatly improved by flattening the bead. This technique allows the diffe rentiation of carbonyl groups of resin-bound compounds with minor stru ctural differences. Three solid-phase reactions on Rink AM, Rink Amide and Wang resins were directly monitored by observing the disappearanc e and the appearance of the resolved carbonyl bands. It was possible t o quantify the yields of two of the solid phase reactions directly on bead.