IRON STATUS AND RESTLESS LEGS SYNDROME IN THE ELDERLY

The relationship between iron status and the restless legs syndrome (R LS) was examined in 18 elderly patients with RLS and in 18 matched con trol subjects. A rating scale with a maximum score of 10 was used to a ssess the severity of RLS symptoms. Serum ferritin levels were reduced in the RLS patients compared with control subjects (median 33 mug/l v s. 59 mug/l, p < 0.01, Wilcoxon signed rank test); serum iron, vitamin B-12 and folate levels and haemoglobin levels did not differ between the two groups. Serum ferritin levels were inversely correlated with t he severity of RLS symptoms (Spearman's rho -0.53, p < 0.05). Fifteen patients with RLS were treated with ferrous sulphate for 2 months. RLS severity score improved by a median value of 4 points in six patients with an initial ferritin less-than-or-equal-to 18 mug/l, by 3 points in four patients with ferritin > 18 mug/l, less-than-or-equal-to 45 mu g/l and by 1 point in five patients with ferritin > 45 mug/l, < 100 mu g/l. Iron deficiency, with or without anaemia, is an important contrib utor to the development of RLS in elderly patients, and iron supplemen ts can produce a significant reduction in symptoms.