EPINIGERICIN TOXICITY TOWARDS TETRAHYMENA-PYRIFORMIS GL - CHANGES IN CELL-VOLUME AND INTRACELLULAR PH

Authors
BAMDAD M DAVID L GROLIERE CA
Citation
M. Bamdad et al., EPINIGERICIN TOXICITY TOWARDS TETRAHYMENA-PYRIFORMIS GL - CHANGES IN CELL-VOLUME AND INTRACELLULAR PH, Applied microbiology and biotechnology, 44(1-2), 1995, pp. 206-209
Citations number
23
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Applied microbiology and biotechnology → ACNP
ISSN journal
01757598
Volume
44
Issue
1-2
Year of publication
1995
Pages
206 - 209
Database
ISI
SICI code
0175-7598(1995)44:1-2<206:ETTTG->2.0.ZU;2-6
Abstract
A study of the toxicity of epinigericin, an antibiotic ionophor, towar ds the ciliate Tetrahymena pyriformis showed that this molecule stoppe d cell division, increased cell volume and led to a more basic intrace llular pH. The action of epinigericin was probably linked to its funct ion as an ionophor. The ionic selectivity of this molecule is still no t known. The raising of the intracellular pH of ciliates by this antib iotic may be linked to its toxic action and its ion-transport mechanis m in Tetrahymena.